Spiro[3H-indole-3,3′-pyrrolidine]-5′-carboxamide, 6-chloro-4′-(3-chloro-2-fluorophenyl)-2′-(2,2-dimethylpropyl)-1,2-dihydro-N-(trans-4-hydroxycyclohexyl)-2-oxo-, (2′R,3S,4′S,5′R)-
MI-773
CAS: 1303607-07-9
Molecular Formula: C29H34Cl2FN3O3
Spiro[3H-indole-3,3′-pyrrolidine]-5′-carboxamide, 6-chloro-4′-(3-chloro-2-fluorophenyl)-2′-(2,2-dimethylpropyl)-1,2-dihydro-N-(trans-4-hydroxycyclohexyl)-2-oxo-, (2′R,3S,4′S,5′R)- - Names and Identifiers
| Name | MI-773 |
| Synonyms | MI-773 MI-773 (2'R,3S-isomer) (2'R,3S,4'S,5'R)-6-Chloro-4'-(3-chloro-2-fluorophenyl)-N-((1r,4R)-4-hydroxycyclohexyl)-2'-neop (2'R,3S,3'S,5'R)-6-chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-N-(4-hydroxycyclohexyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide (2'R,3S,4'S,5'R)-6-Chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-1,2-dihydro-N-(trans-4-hydroxycyclohexyl)-2-oxospiro[3H-indole-3,3'-pyrrolidine]-5'-carboxamide Spiro[3H-indole-3,3′-pyrrolidine]-5′-carboxamide, 6-chloro-4′-(3-chloro-2-fluorophenyl)-2′-(2,2-dimethylpropyl)-1,2-dihydro-N-(trans-4-hydroxycyclohexyl)-2-oxo-, (2′R,3S,4′S,5′R)- |
| CAS | 1303607-07-9 |
Spiro[3H-indole-3,3′-pyrrolidine]-5′-carboxamide, 6-chloro-4′-(3-chloro-2-fluorophenyl)-2′-(2,2-dimethylpropyl)-1,2-dihydro-N-(trans-4-hydroxycyclohexyl)-2-oxo-, (2′R,3S,4′S,5′R)- - Physico-chemical Properties
| Molecular Formula | C29H34Cl2FN3O3 |
| Molar Mass | 562.5 |
| Density | 1.36±0.1 g/cm3(Predicted) |
| Boling Point | 732.1±60.0 °C(Predicted) |
| Solubility | DMSO: ≥ 53 mg/mL |
| pKa | 12.03±0.70(Predicted) |
| Storage Condition | -20℃ |
| In vitro study | MI-773 potently induces expression of p53 and its downstream targets p21, MDM2, and induces phosphorylation of p53 (serine 392) in low passage primary human ACC cells. Notably, MI-773 induces a dose-dependent increase in the fraction of apoptotic ACC cells and in the fraction of cells in the G1 phase of cell cycle (P<0.05). Consequently, MI-773 causes apoptotic cell death. MI-773 is an advanced synthetic small molecule inhibitor, displays high binding affinity against MDM2 (K d =8.2 nM). |
| In vivo study | MI-773 at 10 mg/kg modestly reduces the rate of tumor growth, whereas 100 mg/kg causes significant tumor regression. Control tumors reach an average of 1,000 mm 3 at 20 days of treatment, compare to an average volume of 600 mm 3 for the 10 mg/kg group and 30 mm 3 for the 100 mg/kg group. Kaplan-Meier analysis shows an increase in tumor failure, define as two times increase in tumor volume as compared to pretreatment volume (P=0.044), for vehicle-treated mice when compare to mice treated with 100 mg/kg MI-773. |
Spiro[3H-indole-3,3′-pyrrolidine]-5′-carboxamide, 6-chloro-4′-(3-chloro-2-fluorophenyl)-2′-(2,2-dimethylpropyl)-1,2-dihydro-N-(trans-4-hydroxycyclohexyl)-2-oxo-, (2′R,3S,4′S,5′R)- - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.778 ml | 8.889 ml | 17.778 ml |
| 5 mM | 0.356 ml | 1.778 ml | 3.556 ml |
| 10 mM | 0.178 ml | 0.889 ml | 1.778 ml |
| 5 mM | 0.036 ml | 0.178 ml | 0.356 ml |
Last Update：2024-01-02 23:10:35
Spiro[3H-indole-3,3′-pyrrolidine]-5′-carboxamide, 6-chloro-4′-(3-chloro-2-fluorophenyl)-2′-(2,2-dimethylpropyl)-1,2-dihydro-N-(trans-4-hydroxycyclohexyl)-2-oxo-, (2′R,3S,4′S,5′R)- - Reference Information
| biological activity | MI-773 is a MDM2-p53 interaction inhibitor with high affinity binding to MDM2 with a Ki of 0.88 nM. |
| Target | Ki: 0.88 nM (MDM2) |
Last Update：2024-04-09 20:52:54
![Spiro[3H-indole-3,3′-pyrrolidine]-5′-carboxamide, 6-chloro-4′-(3-chloro-2-fluorophenyl)-2′-(2,2-dimethylpropyl)-1,2-dihydro-N-(trans-4-hydroxycyclohexyl)-2-oxo-, (2′R,3S,4′S,5′R)-](http://res.chembk.com/assets/str/2d/1/13/1303607-07-9.png)
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Product Name: MI-773 Visit Supplier Webpage Request for quotation
CAS: 1303607-07-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 1303607-07-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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Spiro[3H-indole-3,3′-pyrrolidine]-5′-carboxamide, 6-chloro-4′-(3-chloro-2-fluorophenyl)-2′-(2,2-dimethylpropyl)-1,2-dihydro-N-(trans-4-hydroxycyclohexyl)-2-oxo-, (2′R,3S,4′S,5′R)-
亭扎肝素钠
亭扎肝素钠